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CSI 004-18-02 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). CSI 004-18-02 cross-reacts with rabbit and horse vitronectin, no reactivity with human or sheep.
CSI 004-18-02 has been successfully used in ELISA and Immunohistochemistry techniques. CSI 004-18-02 is suitable in ELISA and immunostaining of frozen PLP-fixed sections of bovine tissues.
The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation.
CSI 004-18-02 reacts weakly in ELISA with vitronectin coated directly onto the microtiter plate.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
VTN is a member of the pexin family. This protein is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. The protein is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Glycoprotein 66; S-protein; Serum-spreading factor; Vitronectin; vitronectin (serum spreading factor, somatomedin B, complement S-protein); VN
基因别名: BOS_18542; VN; VTN
UniProt ID: (Rabbit) P22458
Entrez Gene ID: (Bovine) 507525, (Rabbit) 100009128